Prof. ShaneCrottyisaProfessorattheLaJollaInstituteforImmunology, CenterforInfectiousDiseaseandVaccineResearch, CrottyLab. ProfessorCrottyalsohasanacademicappointmentwiththeUniversityofCaliforniaSanDiago. Seehisfullbiohere: https://www.lji.org/labs/crotty/#overview Prof. CrottyonTwitter: https://twitter.com/profshanecrotty
Coronavirus Mutations and COVID 19 Vaccine Implications with Shane Crotty, PhD (SARS CoV 2 Variants)
Professor Shane Crotty, Ph.D. explains recent coronavirus mutations and how they might impact COVID 19 vaccines and transmission. COVID-19 research of Prof. Crotty and his team was published Jan. 6, 2021, in the prestigious Journal Science: https://science.sciencemag.org/content/early/2021/01/05/science.abf4063.full
Prof. Shane Crotty is a Professor at the La Jolla Institute for Immunology, Center for Infectious Disease and Vaccine Research, Crotty Lab. Professor Crotty also has an academic appointment with the University of California San Diago. See his full bio here: https://www.lji.org/labs/crotty/#overview Prof. Crotty on Twitter: https://twitter.com/profshanecrotty
Interviewer: Kyle Allred, Physician Assistant, Producer and Co-Founder of MedCram.com
TOPICS DISCUSSED IN THIS VIDEO INCLUDE:
0:00 Intro 0:08 SARS-CoV-2 / COVID 19 mutations (UK variant etc.) and implications for COVID-19 vaccines 10:58 How to test if coronavirus variants can escape immunity 12:28 How have mutations made this virus more transmissible? 17:44 Could mutations make vaccines less than 50% effective? 24:15 Possible changes to vaccine schedules (one dose, half dose)? 35:34 Could alternate COVID-19 vaccine schedule make mutations more likely? 38:29 What is next for Prof. Crotty and his team?
(This video was recorded on January 5, 2021)
Viral mutations may cause another ‘very, very bad’ COVID-19 wave, scientists warn (Science) | https://www.sciencemag.org/news/2021/01/viral-mutations-may-cause-another-very-very-bad-covid-19-wave-scientists-warn
FDA Statement on Following the Authorized Dosing Schedules for COVID-19 Vaccines | https://www.fda.gov/news-events/press-announcements/fda-statement-following-authorized-dosing-schedules-covid-19-vaccines
S-variant SARS-CoV-2 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-QPCR (MedRxiv) | https://www.medrxiv.org/content/10.1101/2020.12.24.20248834v1.full-text
Human Leukocyte Antigen (HLA) System | https://www.merckmanuals.com/professional/immunology-allergic-disorders/biology-of-the-immune-system/human-leukocyte-antigen-hla-system
UK reports new variant, termed VUI 202012/01 (GISAID) https://www.gisaid.org/references/gisaid-in-the-news/uk-reports-new-variant-termed-vui-20201201/
Covid-19 in South Africa: Scientists seek to understand new variant (BBC) | https://www.bbc.com/news/world-africa-55531838
Mutation Allows Coronavirus to Infect More Cells, Study Finds. Scientists Urge Caution (NY Times) | https://www.nytimes.com/2020/06/12/science/coronavirus-mutation-genetics-spike.html
The UK is delaying second vaccine shots and it’s proving controversial (CNBC) https://www.cnbc.com/2021/01/05/the-uk-is-delaying-second-pfizer/biontech-shot-heres-what-we-know.html
The receptor binding domain of the SARS-CoV-2 (News Medical Life Sciences) | https://www.news-medical.net/news/20200608/The-receptor-binding-domain-of-the-SARS-CoV-2.aspx
New York Times article highlighting Prof. Shane Crotty's research: https://www.nytimes.com/2020/11/17/health/coronavirus-immunity.html
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